Functional NF-IL6/CCAAT Enhancer-binding Protein is Required for Tumor Necrosis Factor c~-inducible Expression of the Granulocyte Colony-stimulating Factor (CSF), but not the Granulocyte/Macrophage CSF or Interleukin 6 Gene in Human Fibroblasts
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چکیده
NF-IL6/CCAAT enhancer-binding protein is required for tumor necrosis factor ␣-inducible expression of the granulocyte colony-stimulating factor (CSF), but not the granulocyte/macrophage CSF or interleukin 6 gene in human fibroblasts. The Editorial Board of The Journal of Experimental Medicine regrets to inform its readership that due to scientific misconduct, the results of the above named paper are not valid. A letter dated April 30, 1997 was received from Guido Adler, M.D., the Dean of the School of Medicine at the University of Ulm. In his letter, Dr. Adler states that " fraud was uncovered in the laboratory of Friedhelm Herrmann and Marion Brach. In a series of papers major results were fabricated [including]:. .. In addition to his letter, a signed statement from each of the authors agreeing to the retraction of this article is on file at Rockefeller University Press.
منابع مشابه
Functional NF-IL6/CCAAT enhancer-binding protein is required for tumor necrosis factor alpha-inducible expression of the granulocyte colony- stimulating factor (CSF), but not the granulocyte/macrophage CSF or interleukin 6 gene in human fibroblasts [retracted by Adler G. In: J Exp Med 1997 Jul 7;186(1):171]
Tumor necrosis factor (TNF) alpha participates in the regulation of the acute-phase, immune, and inflammatory responses. Target genes known to be transcriptionally activated by TNF-alpha include the granulocyte (G)-colony-stimulating factor (CSF) gene, the granulocyte/macrophage (GM)-CSF gene, as well as the interleukin (IL) 6 gene. Functional nuclear factor (NF)-IL6 recognition sites have been...
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تاریخ انتشار 1997